Elucidating acquired PARP inhibitor resistance in advanced prostate cancer.

doi:10.1016/j.ccell.2024.10.015

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Elucidating acquired PARP inhibitor resistance in advanced prostate cancer.

Cancer cell - 9 Dec 2024

Seed George, Beije Nick, Yuan Wei, Bertan Claudia, Goodall Jane, Lundberg Arian, Tyler Matthew, Figueiredo Ines, Pereira Rita, Baker Chloe, Bogdan Denisa, Gallagher Lewis, Cieslik Jan-Phillipp, Greening Semini, Lambros Maryou, Neves Rui, Magraner-Pardo Lorena, Fowler Gemma, Ebbs Berni, Miranda Susana, Flohr Penny, Bianchini Diletta, Rescigno Pasquale, Porta Nuria, Hall Emma, Gurel Bora, Tunariu Nina, Sharp Adam, Pettit Stephen, Stoecklein Nikolas H, Sandhu Shahneen, Quigley David, Lord Christopher J, Mateo Joaquin, Carreira Suzanne, de Bono Johann

Abstract excerpt

PARP inhibition (PARPi) has anti-tumor activity against castration-resistant prostate cancer (CRPC) with homologous recombination repair (HRR) defects. However, mechanisms underlying PARPi resistance are not fully understood. While acquired mutations restoring BRCA genes are well documented, their clinical relevance, frequency, and mechanism of generation remain unclear. Moreover, how resistance emerges in BRCA2...

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Identifiers

PMID: 39577422
DOI: 10.1016/j.ccell.2024.10.015

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