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Examining genotype-phenotype associations of GRAM domain proteins using GWAS, PheWAS and literature review in cattle, human, pig, mouse and chicken.

Scientific reports - 21 Nov 2024

Kunej Tanja, Šimon Martin, Luštrek Barbara, Horvat Simon, Potočnik Klemen

Abstract excerpt

The GRAMD genes are involved in maintaining cholesterol homeostasis, apoptosis, cancer and production traits in livestock. A lipid-binding GRAM domain is implicated in lipid transport and metabolism. The functions of GRAMD proteins remain incompletely understood. The aim of the present study was therefore to investigate the associations between six GRAMD genes in cattle using data from the international genomic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 39572677
DOI: 10.1038/s41598-024-80117-7
PMCID: PMC11582632

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