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Article

The KLF16/MYC feedback loop is a therapeutic target in bladder cancer

17 Nov 2024

Abstract excerpt

BACKGROUND: Bladder cancer (BLCA) is a common malignancy characterized by dysregulated transcription and a lack of effective therapeutic targets. In this study, we aimed to identify and evaluate novel targets with clinical potential essential for tumor growth in BLCA. METHODS: CRISPR-Cas9 screening was used to identify transcription factors essential for bladder cancer cell viability. The biological functions of...

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PMID: 39551759
DOI: 10.1186/s13046-024-03224-3

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