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AI tool for predicting MGMT methylation in glioblastoma for clinical decision support in resource limited settings

14 Nov 2024

Abstract excerpt

Glioblastoma is an aggressive brain cancer with a poor prognosis. The O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status is crucial for treatment stratification, yet economic constraints often limit access. This study aims to develop an artificial intelligence (AI) framework for predicting MGMT methylation. Diagnostic magnetic resonance (MR) images in public repositories were used for training....

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PMID: 39543155
DOI: 10.1038/s41598-024-78189-6

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