A data-driven scientific approach to explore the relationship between MGMT methylation and imaging phenotype in glioblastoma.

doi:10.1007/s12194-026-01068-4

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Article

A data-driven scientific approach to explore the relationship between MGMT methylation and imaging phenotype in glioblastoma.

Radiological physics and technology - 1 Sept 2026

Sugyo Sakura, Ishii Mio, Soufi Mazen, Uchiyama Yoshikazu

Abstract excerpt

Glioblastoma is a highly malignant brain tumor, and patient survival remains short despite multimodal treatment. One important prognostic factor is the methylation status of the O⁶-methylguanine DNA methyltransferase (MGMT) gene, as MGMT promoter methylation is associated with a better response to temozolomide chemotherapy. The aim of this study was to evaluate the association between noninvasively obtained...

Read the complete abstract on PubMed

Topics

Humans
Glioblastoma
DNA Modification Methylases
DNA Repair Enzymes
Tumor Suppressor Proteins
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Brain Neoplasms

Magnetic Resonance Imaging

Radiomics

Phenotype

Female

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 42183985
DOI: 10.1007/s12194-026-01068-4

Genes

MGMT

Provenance

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