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Temporin-Derived Peptides Disrupt the Exopolysaccharide Matrix of Streptococcus mutans to Prevent Related Dental Caries

13 Nov 2024

Abstract excerpt

Dental caries, the most prevalent oral infectious disease, is closely associated with Streptococcus mutans . This study investigates the antimicrobial properties of the temporin-GHb peptide and its derivatives (GHbR, GHbK, and GHb3K) against S. mutans . These peptides exhibited potent anti - S. mutans activity through a membrane-disruptive mechanism, confirmed by flow cytometry and fluorescence staining assays...

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PMID: 39535250
DOI: 10.1021/acs.jafc.4c09488

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