Article
HPV is an essential driver in recurrence of cervical cancer.
Pathology, research and practice - 1 Dec 2024
Bønløkke Sara, Stougaard Magnus, Blaakær Jan, Bertelsen Jesper, Andersen Karoline, Fuglsang Katrine, Steiniche Torben
Abstract excerpt
INTRODUCTION: High-risk human papillomavirus (HPV) has been detected in distant metastases from cervical cancer (CC) patients, suggesting a role of HPV. MATERIAL AND METHODS: Here, we included 26 patients with recurrence of CC (2019-2023). With next generation sequencing (NGS) and immunohistochemical staining, primary and recurrent tissues were analyzed for HPV DNA and HPV RNA, p16INK4a expression, and somatic...
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