Article
Generation of an integration-free induced pluripotent stem cell line, FJMAi001-A, from a Marfan syndrome patient with a heterozygous mutation c.2777G > A (p.Cys926Tyr) in FBN1.
Stem cell research - 1 Dec 2024
Liu Ronghua, Weng Guoxing, Zheng Fuzhen, Chen Jinyan, Wang Kun, Han Junyong, Huang Jie, Yan Licheng, Jin Jingjun
Abstract excerpt
Marfan syndrome (MFS) is a heritable dominant disorder of fibrous connective tissue, caused by mutations in the gene encoding fibrillin-1 on chromosome 15. Here, we report an induced pluripotent stem cell (iPSC) line generated from a patient with MFS who carries a heterozygous mutation of c.2777G > A(p.Cys926Tyr) in the FBN1 gene using an episomal method. The hiPS-MFS cell line has normal karyotype, expresses...
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