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Article

Substrate specificity and protein stability drive the divergence of plant-specific DNA methyltransferases.

Science advances - 8 Nov 2024

Jiang Jianjun, Gwee Jia, Fang Jian, Leichter Sarah M, Sanders Dean, Ji Xinrui, Song Jikui, Zhong Xuehua

Abstract excerpt

DNA methylation is an important epigenetic mechanism essential for transposon silencing and genome integrity. Across evolution, the substrates of DNA methylation have diversified between kingdoms. In plants, chromomethylase3 (CMT3) and CMT2 mediate CHG and CHH methylation, respectively. However, how these two methyltransferases diverge on substrate specificities during evolution remains unknown. Here, we reveal...

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Identifiers

PMID: 39504374
DOI: 10.1126/sciadv.adr2222
PMCID: PMC11540031

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