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Article

Alternative splicing in the genome of HPV and its regulation

22 Oct 2024

Abstract excerpt

Persistent infection with high-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer. These chronic infections are characterized by high expression of the HPV E6 and E7 oncogenes and the absence of the L1 and L2 capsid proteins. The regulation of HPV gene expression plays a crucial role in both the viral life cycle and rare oncogenic events. Alternative splicing of HPV mRNA is a key mechanism in...

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PMID: 39502170
DOI: 10.3389/fcimb.2024.1443868

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