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Article

KRAS G12C mutation in NSCLC in a small genetic center: insights into sotorasib therapy response potential.

Scientific reports - 4 Nov 2024

Eser Metin, Hekimoglu Gulam, Yarar Murat Hakki, Canbek Sezin, Ozcelik Melike

Abstract excerpt

Lung cancer remains a significant health challenge, characterized by aberrant tissue growth within the pulmonary system. Early carcinogenic events often involve genomic instability and the emergence of a mutator phenotype. In this study, we aimed to explore the mutator phenotype in 89 patients diagnosed with non-small-cell lung cancer (NSCLC). RNA isolation from formalin-fixed paraffin-embedded (FFPE) tissue...

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Identifiers

PMID: 39496639
DOI: 10.1038/s41598-024-75208-4
PMCID: PMC11535051

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