Article
TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells.
PloS one - 1 Jan 2015
Otani Hiroki, Yamamoto Hiromasa, Takaoka Munenori, Sakaguchi Masakiyo, Soh Junichi, Jida Masaru, Ueno Tsuyoshi, Kubo Takafumi, Asano Hiroaki, Tsukuda Kazunori, Kiura Katsuyuki, Hatakeyama Shinji, Kawahara Eiji, Naomoto Yoshio, Miyoshi Shinichiro, Toyooka Shinichi
Abstract excerpt
TAE226, a bis-anilino pyrimidine compound, has been developed as an inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor-I receptor (IGF-IR). In this study, we investigated the effect of TAE226 on non-small-cell lung cancer (NSCLC), especially focusing on the EGFR mutational status. TAE226 was more effective against cells with mutant EGFR, including the T790M mutant, than against cells with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.