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Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replication

1 Nov 2024

Abstract excerpt

The current antiviral agents for the treatment of chronic infection with hepatitis B virus (HBV) do not completely remove covalently closed circular DNA (cccDNA) and integrated viral DNA fragments from patients. Berberine is an isoquinoline alkaloid extracted from various plants and has been reported to inhibit the replication of various types of DNA. In this study, we tested the effects of berberine and its...

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PMID: 39489302
DOI: 10.1016/j.antiviral.2024.106027

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