Article
KRAS-dependent cancer cells promote survival by producing exosomes enriched in Survivin.
Cancer letters - 1 Oct 2021
Chang Wen-Hsuan, Nguyen Thuy-Tien Thi, Hsu Chia-Hsin, Bryant Kirsten L, Kim Hong Jin, Ying Haoqiang, Erickson Jon W, Der Channing J, Cerione Richard A, Antonyak Marc A
Abstract excerpt
Mutations in KRAS frequently occur in human cancer and are especially prevalent in pancreatic ductal adenocarcinoma (PDAC), where they have been shown to promote aggressive phenotypes. However, targeting this onco-protein has proven to be challenging, highlighting the need to further identify the various mechanisms used by KRAS to drive cancer progression. Here, we considered the role played by exosomes, a...
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