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Article

Genedrive kit for detecting single nucleotide polymorphism m.1555A>G in neonates and their mothers: a systematic review and cost-effectiveness analysis.

Health technology assessment (Winchester, England) - 1 Oct 2024

Shabaninejad Hosein, Kenny Ryan Pw, Robinson Tomos, Stoniute Akvile, O'Keefe Hannah, Still Madeleine, Thornton Christopher, Pearson Fiona, Beyer Fiona, Meader Nick

Abstract excerpt

Background: Neonates with suspected sepsis are commonly treated with gentamicin, an aminoglycoside. These antibiotics are associated with high risk of ototoxicity, including profound bilateral deafness, in people with the m.1555A>G mitochondrial genetic variant. Objective: This early value assessment summarised and critically assessed the clinical effectiveness and cost-effectiveness of the Genedrive MT-RNR1 ID...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39487741
DOI: 10.3310/TGAC4201
PMCID: PMC11590116

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