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Article

Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses.

Science advances - 1 Nov 2024

Cole Megan, Anastasiou Panayiotis, Lee Claudia, Yu Xiaofei, de Castro Andrea, Roelink Jannes, Moore Chris, Mugarza Edurne, Jones Martin, Valand Karishma, Rana Sareena, Colliver Emma, Angelova Mihaela, Enfield Katey S S, Magness Alastair, Mullokandov Asher, Kelly Gavin, de Gruijl Tanja D, Molina-Arcas Miriam, Swanton Charles, Downward Julian, van Maldegem Febe

Abstract excerpt

Kirsten rat sarcoma virus (KRAS)-G12C inhibition causes remodeling of the lung tumor immune microenvironment and synergistic responses to anti-PD-1 treatment, but only in T cell infiltrated tumors. To investigate mechanisms that restrain combination immunotherapy sensitivity in immune-excluded tumors, we used imaging mass cytometry to explore cellular distribution in an immune-evasive KRAS mutant lung cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39485838
DOI: 10.1126/sciadv.adl6464
PMCID: PMC11529713

Genes

KRAS
CD4
CXCL9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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