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Article

Detectability of runs of homozygosity is influenced by analysis parameters and population-specific demographic history.

PLoS computational biology - 1 Oct 2024

Silva Gabriel A A, Harder Avril M, Kirksey Kenneth B, Mathur Samarth, Willoughby Janna R

Abstract excerpt

Wild populations are increasingly threatened by human-mediated climate change and land use changes. As populations decline, the probability of inbreeding increases, along with the potential for negative effects on individual fitness. Detecting and characterizing runs of homozygosity (ROHs) is a popular strategy for assessing the extent of individual inbreeding present in a population and can also shed light on...

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PMID: 39480880
DOI: 10.1371/journal.pcbi.1012566
PMCID: PMC11556709

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