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Epigenetic DNA modifications and vitamin C in prostate cancer and benign prostatic hyperplasia: Exploring similarities, disparities, and pathogenic implications

30 Oct 2024

Abstract excerpt

• Characteristic DNA methylation/hydroxymethylation changes have been observed in both PC and BPH, suggesting potential shared molecular pathways between the two conditions. • Diminished levels of 5-hydroxymethylcytosine may extend beyond tumor tissue to include surrogate tissues like leukocytes, indicating systemic alterations in epigenetic modifications during tumor progression. • Factors such as chronic...

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PMID: 39471555
DOI: 10.1016/j.neo.2024.101079

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