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The inflammatory and oxidative phenotype of gestational diabetes is epigenetically transmitted to the offspring: role of methyltransferase MLL1-induced H3K4me3.

European heart journal - 23 Dec 2024

Di Pietrantonio Nadia, Sánchez-Ceinos Julia, Shumliakivska Mariana, Rakow Alexander, Mandatori Domitilla, Di Tomo Pamela, Formoso Gloria, Bonfini Tiziana, Baldassarre Maria Pompea Antonia, Sennström Maria, Almahmeed Wael, Pandolfi Assunta, Cosentino Francesco

Abstract excerpt

BACKGROUND AND AIMS: Hyperglycaemia during gestational diabetes (GD) predisposes women and their offspring to later cardiometabolic disease. The hyperglycaemia-mediated epigenetic changes remain to be elucidated. Methyltransferase MLL1-induced trimethylation of histone 3 at lysine 4 (H3K4me3) activates inflammatory and oxidative phenotype. This epigenetic mark in GD women and its transmission to the offspring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39471481
DOI: 10.1093/eurheartj/ehae688

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