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Article

TM6SF2 -rs58542926 Genotype Has Opposing Effects on Incidence of Hepatic and Cardiac Events in a Community Cohort.

The American journal of gastroenterology - 30 Oct 2024

Chen Vincent L, Oliveri Antonino, Raut Chinmay, Chen Yanhua, Cushing-Damm Kelly C, Speliotes Elizabeth K

Abstract excerpt

INTRODUCTION: TM6SF2 -rs58542926-T is associated with increased cirrhosis and modestly decreased coronary artery disease prevalence. However, relative effects of TM6SF2 genotype on major adverse cardiovascular events (MACE) vs liver-related events (LRE) are not known. METHODS: We used the UK Biobank, a prospective cohort with genetic and inpatient diagnosis data. The primary predictor was TM6SF2 -rs58542926...

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Identifiers

PMID: 39471479
DOI: 10.14309/ajg.0000000000003169
PMCID: PMC12041304

Genes

TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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