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Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors

2 Jan 2025

Abstract excerpt

Cross-species transmission of animal viruses poses a threat to human health. However, systematic experimental assessments of these risks remain scarce. A critical step in viral infection is cellular internalization mediated by viral receptor-binding proteins (RBPs). Here we constructed viral pseudotypes bearing the RBPs of 102 enveloped RNA viruses and assayed their infectivity across 5,202 RBP-cell combinations....

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PMID: 39747691
DOI: 10.1038/s41564-024-01879-4

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