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Article

Evaluation of the Role of Tanshinone I in an In Vitro System of Charcot-Marie-Tooth Disease Type 2N.

International journal of molecular sciences - 17 Oct 2024

Zhang Jingjing, Meng Xinru, Qin Qianni, Liang Yali, Yang Guangpu, Li Shen, Li Xiaorong, Zhou Ji-Chang, Sun Litao

Abstract excerpt

Charcot-Marie-Tooth disease type 2N (CMT2N) is an inherited nerve disorder caused by mutations in the alanyl-tRNA synthetase (AlaRS) gene, resulting in muscle weakness and sensory issues. Currently, there is no cure for CMT2N. Here, we found that all five AlaRS mutations in the aminoacylation domain can interact with neuropilin-1 (Nrp1), which is consistent with our previous findings. Interestingly, three of...

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Identifiers

PMID: 39456965
DOI: 10.3390/ijms252011184
PMCID: PMC11509018

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