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Intranasal administration of recombinant human BDNF as a potential therapy for some primary headaches

25 Oct 2024

Abstract excerpt

BACKGROUND: In addition to its critical role in neurogenesis, brain-derived neurotrophic factor (BDNF) modulates pain and depressive behaviors. METHODS: In a translational perspective, we tested the anti-migraine activity of highly purified and characterized recombinant human BDNF (rhBDNF) in an animal model of cephalic pain based on the chronic and intermittent NTG administration (five total injections over nine...

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PMID: 39455939
DOI: 10.1186/s10194-024-01890-4

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