Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain

27 Aug 2024

Abstract excerpt

Bone cancer pain (BCP) represents a prevalent symptom among cancer patients with bone metastases, yet its underlying mechanisms remain elusive. This study investigated the transcriptional regulation mechanism of Kv7(KCNQ)/M potassium channels in DRG neurons and its involvement in the development of BCP in rats. We show that HDAC2-mediated transcriptional repression of kcnq2/kcnq3 genes, which encode Kv7(KCNQ)/M...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Treatment and Pharmacology
Share to Ion channel regulation and function
Share to Pain Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39192337
DOI: 10.1186/s12964-024-01797-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer painPMID 39192337Read ↗

Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent modelsSemantic proximity Read ↗

LncRNA01103/FGF13 axis promotes the progression of bone cancer pain by remodeling ac4C modificationSemantic proximity Read ↗

Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancerSemantic proximity Read ↗

Comprehensive pan‑cancer analysis of potassium voltage-gated channel Q4 (KCNQ4) gene across multiple human malignant tumors.Semantic proximity Read ↗

G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transitionSemantic proximity Read ↗

Neurobiology of Cancer Pain: A Narrative ReviewSemantic proximity Read ↗

Na <sub>v</sub> 1.5 expressed in TrkB <sup>+</sup> sensory neurons mediates paclitaxel-induced mechanical pain hypersensitivitySemantic proximity Read ↗

Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer.Semantic proximity Read ↗

Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: Etiological contribution to complex regional pain syndromes (Part I)Semantic proximity Read ↗

Comprehensive pan‑cancer analysis of Potassium Voltage-Gated Channel Q4 (KCNQ4 ) gene expression in human malignant tumorsSemantic proximity Read ↗

Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysisSemantic proximity Read ↗

TrkA <sup>+</sup> sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.