Article
Mice with lymphatic dysfunction develop pathogenic lung tertiary lymphoid organs that model an autoimmune emphysema phenotype of COPD.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2025
Summers Barbara, Kim Kihwan, Trivedi Anjali, Lu Tyler M, Houghton Sean, Palmer-Johnson Jade, Rojas-Quintero Joselyn, Cala-Garcia Juan, Pannellini Tania, Polverino Francesca, Lis Raphaël, Reed Hasina Outtz
Abstract excerpt
We have previously shown that mice with a loss of C-type lectin-like type II (CLEC2), which have lymphatic dysfunction due to the role of CLEC2 in platelets for maintaining separation between the venous and lymphatic system, develop lung tertiary lymphoid organ (TLO) formation and lung injury that resembles an emphysema phenotype of chronic obstructive pulmonary disease (COPD). We now sought to investigate...
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