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EBV infection alters DNA methylation in primary human colon cells: A path to inflammation and carcinogenesis?

18 Oct 2024

Abstract excerpt

Epstein-Barr Virus (EBV) is associated with several types of human cancers, and changes in DNA methylation are reported to contribute to viral-driven carcinogenesis, particularly in cancers of epithelial origin. In a previous study, we demonstrated that EBV infects human primary colonic cells (HCoEpC) and replicates within these cells, leading to pro-inflammatory and pro-tumorigenic effects. Notably, these...

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PMID: 39427708
DOI: 10.1016/j.bbagrm.2024.195064

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