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Article

Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study.

International journal of molecular sciences - 1 Oct 2024

Ramírez-Pacheco Arturo, Moreno-Guerrero Silvia Selene, Rocha-Ramírez Luz María, Hernández-Pliego Gabriela, Escobar-Sánchez María Argelia, Reyes-López Alfonso, Sienra-Monge Juan José Luis, Juárez-Villegas Luis Enrique

Abstract excerpt

The results of in vitro and in vivo studies have shown the pro-tumor effects of TNF-α, and this cytokine's increased expression is associated with poor prognosis in patients with some types of cancer. Our study objective was to evaluate the possible association of TNF-α genetic polymorphisms and serum levels with susceptibility and prognosis in a cohort of Mexican patients with NB. We performed PCR-RFLP and ELISA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39408920
DOI: 10.3390/ijms251910590
PMCID: PMC11477149

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