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Article

A mendelian randomization analysis of the associations between haptoglobin and multiple sclerosis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Dec 2024

Huang Xingxiao, Zeng Qian, Hu Yachun, Shi Xiaolei

Abstract excerpt

BACKGROUND: Observational studies have suggested an association between plasma haptoglobin and multiple sclerosis (MS). Haptoglobin plays an important role in the pathogenesis of MS. However, whether it has a causal effect on MS remains unknown. METHODS: We here used a two-sample bidirectional Mendelian randomization (MR) method to investigate the causality between haptoglobin and MS. Genetic variants associated...

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PMID: 39400787
DOI: 10.1007/s10072-024-07786-0

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