Direct genome sequencing of respiratory viruses from low viral load clinical specimens using the target capture sequencing technology

Abstract excerpt

The use of metagenomic next-generation sequencing technology to obtain complete viral genome sequences directly from clinical samples with low viral load remains challenging-especially in the case of respiratory viruses-due to the low copy number of viral versus host genomes. To overcome this limitation, target capture sequencing for the enrichment of specific genomes has been developed and applied for direct...

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