Article
Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome.
Scientific reports - 12 Oct 2024
Nagashima Takeshi, Yamaguchi Ken, Urakami Kenichi, Shimoda Yuji, Ohnami Sumiko, Ohshima Keiichi, Tanabe Tomoe, Naruoka Akane, Kamada Fukumi, Serizawa Masakuni, Hatakeyama Keiichi, Ohnami Shumpei, Maruyama Koji, Mochizuki Tohru, Mizuguchi Maki, Shiomi Akio, Ohde Yasuhisa, Bando Etsuro, Sugiura Teiichi, Mukaigawa Takashi, Nishimura Seiichiro, Hirashima Yasuyuki, Mitsuya Koichi, Yoshikawa Shusuke, Kiyohara Yoshio, Tsubosa Yasuhiro, Katagiri Hirohisa, Niwakawa Masashi, Takahashi Kaoru, Kashiwagi Hiroya, Yasunaga Yoshichika, Ishida Yuji, Sugino Takashi, Kenmotsu Hirotsugu, Terashima Masanori, Takahashi Mitsuru, Uesaka Katsuhiko, Akiyama Yasuto
Abstract excerpt
In cancer genome analysis, identifying pathogenic alterations and assessing their effects on oncogenic processes is important. Although whole exome sequencing (WES) can effectively detect such changes, driver alterations could not be identified in 27.8% of the cases, according to a previous study. The objectives of the present study were to evaluate the utility of whole genome sequencing (WGS) and clarify its...
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