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Article

Spatial multiomics atlas reveals smooth muscle phenotypic transformation and metabolic reprogramming in diabetic macroangiopathy.

Cardiovascular diabetology - 12 Oct 2024

Qian Yongjiang, Xiong Shizheng, Li Lihua, Sun Zhen, Zhang Lili, Yuan Wei, Cai Honghua, Feng Guoquan, Wang Xiaoguang, Yao Haipeng, Gao Yun, Guo Li, Wang Zhongqun

Abstract excerpt

BACKGROUND: Diabetic macroangiopathy has been the main cause of death and disability in diabetic patients. The mechanisms underlying smooth muscle cell transformation and metabolic reprogramming other than abnormal glucose and lipid metabolism remain to be further explored. METHOD: Single-cell transcriptome, spatial transcriptome and spatial metabolome sequencing were performed on anterior tibial artery from 11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39395983
DOI: 10.1186/s12933-024-02458-x
PMCID: PMC11471023

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