Article
Fast and accurate DNASeq variant calling workflow composed of LUSH toolkit.
Human genomics - 10 Oct 2024
Wang Taifu, Zhang Youjin, Wang Haoling, Zheng Qiwen, Yang Jiaobo, Zhang Tiefeng, Sun Geng, Liu Weicong, Yin Longhui, He Xinqiu, You Rui, Wang Chu, Liu Zhencheng, Liu Zhijian, Wang Jin'an, Jin Xiangqian, He Zengquan
Abstract excerpt
BACKGROUND: Whole genome sequencing (WGS) is becoming increasingly prevalent for molecular diagnosis, staging and prognosis because of its declining costs and the ability to detect nearly all genes associated with a patient's disease. The currently widely accepted variant calling pipeline, GATK, is limited in terms of its computational speed and efficiency, which cannot meet the growing analysis needs. RESULTS:...
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