Article
Production of norovirus VLPs of the nine representative genotypes widely distributed in Japan using the silkworm-baculovirus expression vector system.
Journal of virological methods - 1 Jan 2025
Tsurumi Yuto, Morimoto Keisuke, Masuda Akitsu, Lee Jae Man, Mon Hiroaki, Kusakabe Takahiro
Abstract excerpt
Norovirus (NoV) is one of the major causes of acute viral gastroenteritis in humans. Genetic variation is abundant, and prevalent genotypes vary from year to year and region to region. Since NoVs are difficult to amplify in cultured cells, genome RNA-free virus-like particles (VLPs) that mimic the capsid structure of the virus are promising vaccine candidates for the prevention of NoVs infection, and the...
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