Therapeutic Potential of Mesenchymal Stem Cell–Derived Extracellular Vesicles Carrying MicroRNAs for Modulating Autophagy and Cellular Degeneration in Intervertebral Disc Degeneration

Abstract excerpt

STUDY DESIGN: This research utilized bioinformatics and in vitro modeling to assess the effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) containing specific microRNAs (miRNAs) on the autophagy and degeneration of nucleus pulposus cells in intervertebral disc degeneration (IDD). OBJECTIVE: To determine the therapeutic potential of MSC-EVs loaded with miRNAs in modulating pathologic changes...

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