Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1.

Journal of genetics and genomics = Yi chuan xue bao - 1 Dec 2024

Chen Yayue, Huang Delai, Xie Aixuan, Shan Ying, Zhao Shuyi, Gao Ce, Chen Jun, Shi Hui, Fang Weihuan, Peng Jinrong

Abstract excerpt

Mutations in calcium-dependent papain-like protease CALPAIN3 (CAPN3) cause Limb-Girdle Muscular Dystrophy Recessive Type 1 (LGMDR1), the most common limb-girdle muscular dystrophy in humans. In addition to progressive muscle weakness, persistent inflammatory infiltration is also a feature of LGMDR1. Despite the underlying mechanism remaining poorly understood, we consider that it may relate to the newly defined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calpain
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Muscle Proteins

Share to Muscular Dystrophies, Limb-Girdle

Share to Mutation

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 39349278
DOI: 10.1016/j.jgg.2024.09.011

Genes

CAPN3
NKAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1.PMID 39349278Read ↗

CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)Semantic proximity Read ↗

An eccentric calpain, CAPN3/p94/calpain-3.Semantic proximity Read ↗

Missense mutation of c.635 T > C in CAPN3 impairs muscle injury repair in a Limb-Girdel Muscular Dystropy Model.Semantic proximity Read ↗

The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosisSemantic proximity Read ↗

Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.Semantic proximity Read ↗

Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction.Semantic proximity Read ↗

Identification of novel pathogenic variants of Calpain-3 gene in limb girdle muscular dystrophy R1.Semantic proximity Read ↗

Oligomer-dependent and oligomer-independent pathogenesis of muscular dystrophy-associated mutations within the penta-EF-hand domain of calpain-3.Semantic proximity Read ↗

Limb-girdle muscular dystrophy 2A.Semantic proximity Read ↗

Compound heterozygous CAPN3 variants identified in a family with limb-girdle muscular dystrophy recessive 1.Semantic proximity Read ↗

Negative Regulator Nlrc3-like Maintain the Balanced Innate Immune Response During Mycobacterial Infection in ZebrafishSemantic proximity Read ↗

Viewing Inflammation and Immunoregulation Under the Calpain System LensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.