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Changes in Innate Immunity and Microbiome in Different Aging Phenotypes.

Bulletin of experimental biology and medicine - 1 Sept 2024

Gankovskaya L V, Svitich O A, Poddubikov A V, Burmakina V V, Khasanova E M, Gorodishchenskaya S V

Abstract excerpt

The indicators of innate immunity and the composition of the microbiome in the nasopharyngeal mucosa in centenarians with different aging phenotypes were analyzed. A significant increase in the expression of pattern-recognizing receptor genes (TLR2, TLR4, and NLRP3) and proinflammatory cytokines (IL1B, IL18) was shown in the group of centenarians with pathological aging phenotype. In centenarians with successful...

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PMID: 39340620
DOI: 10.1007/s10517-024-06244-3

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