Article
Improved polygenic risk prediction in migraine-first patients.
The journal of headache and pain - 27 Sept 2024
Torok Dora, Petschner Peter, Baksa Daniel, Juhasz Gabriella
Abstract excerpt
BACKGROUND: Recent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30-60%. This study aimed to investigate heritability estimates in "migraine-first" individuals, patients for whom G43 (migraine with or without aura) was their first medical diagnosis in their lifetime. FINDINGS: Using data from the UK Biobank (N = 199,929), genome-wide...
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