Article
Whole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of β-thalassemia.
Genomics, proteomics & bioinformatics - 30 May 2025
Wang Xingmin, Zhang Qianqian, Chen Xianming, Huang Yushan, Zhang Wei, Liao Liuhua, Zhang Xinhua, Huang Binbin, Huang Yueyan, Ye Yuhua, Song Mengyang, Lao Jinquan, Chen Juanjuan, Feng Xiaoqin, Long Xingjiang, Liu Zhixiang, Zhu Weijian, Yu Lian, Fan Chengwu, Tang Deguo, Zhong Tianyu, Fang Mingyan, Li Caiyun, Niu Chao, Huang Li, Lin Bin, Hua Xiaoyun, Jin Xin, Li Zilin, Xu Xiangmin
Abstract excerpt
Platelets act as a crucial indicator for monitoring hypercoagulability and thrombosis and a key target for pharmacological intervention. Genotype-phenotype association studies have confirmed that platelet traits are quantitatively regulated by multiple genes. However, there is currently a lack of genetic studies on the heterogeneity of platelet traits in β-thalassemia under a hypercoagulable state. Here, we...
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