Article
A content analysis of parents' reflections on pathogenic and uncertain pediatric oncology germline sequencing results.
Familial cancer - 1 Nov 2024
Howard Sharp Katianne M, Clark Mary Egan, Jurbergs Niki, Ouma Annastasia, Harrison Lynn, Taylor Leslie, Hamilton Kayla, McGee Rose B, Nuccio Regina, Hines-Dowell Stacy, Gattuso Jami S, Pritchard Michelle, Mandrell Belinda, Tercyak Kenneth P, Johnson Liza-Marie, Nichols Kim E
Abstract excerpt
Germline genomic sequencing is increasingly integrated into pediatric cancer care, with pathogenic cancer-predisposing variants identified among 5-18% of affected children and variants of uncertain significance (VUS) in up to 70%. Given the potential medical implications for children and their families, parents' psychosocial responses to learning results are important to understand. Parents of children with...
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