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Article

Construction and evaluation of a Salmonella Paratyphi A vaccine candidate based on a poxA gene mutation.

Gene - 15 Jan 2025

You Yonghe, Zhao Xiaohui, Jie Jiayue, Xie Yongsheng, Hao Zhenhua, He Qunli, Zhou Yanlin

Abstract excerpt

Salmonella Paratyphi A, the pathogen of paratyphoid A accounts for an obviously growing proportion of cases in many areas. Therefore, development of specific paratyphoid A vaccines is needed. In the present study, the poxA gene of Salmonella Paratyphi A, encoding the aminoacyl-tRNA synthetase, was deleted successfully by the method of lambda Red recombination system, the resulting strain, ΔpoxA was characterized...

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PMID: 39299530
DOI: 10.1016/j.gene.2024.148952

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