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Matrix stiffness regulates the protein profile of extracellular vesicles of pancreatic cancer cell lines

16 Sept 2024

Abstract excerpt

Abstract The fibrotic stroma characterizing pancreatic ductal adenocarcinoma (PDAC) derives from a progressive tissue rigidification, which induces epithelial mesenchymal transition and metastatic dissemination. The aim of this study was to investigate the influence of matrix stiffness on PDAC progression by analyzing the proteome of PDAC‐derived extracellular vesicles (EVs). PDAC cell lines (mPDAC and KPC) were...

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PMID: 39279557
DOI: 10.1002/pmic.202400058

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