Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab.

Cancer biomarkers : section A of Disease markers - 1 Jan 2024

Mohamed Yehia I, Lee Sunyoung S, Demir Tarik, Chamseddine Shadi, Hu Zishuo Ian, Xiao Lianchun, Elsayes Khaled, Morris Jeffrey S, Wolff Robert A, Hiatia Rikita, Qayyum Aliya, Rashid Asif, Duda Dan G, Yao James C, LaPelusa Michael, Koay Eugene J, Mahvash Armeen, Al Azzam Ahmed, Dumbrava Ecaterina E, Hassan Manal, Amin Hesham M, Kaseb Ahmed Omar

Abstract excerpt

BACKGROUND: Circulating tumor DNA (ctDNA) is a promising non-invasive marker for detection, diagnosis, treatment selection, and prognosis of hepatocellular carcinoma (HCC). OBJECTIVE: This study aimed to examine the utility of ctDNA as a prognostic and predictive tool in HCC patients treated with nivolumab. METHODS: We analyzed pre-treatment ctDNA from 44 HCC patients using comprehensive genomic testing on a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents, Immunological

Share to Biomarkers, Tumor

Share to Carcinoma, Hepatocellular

Share to Circulating Tumor DNA

Share to Liver Neoplasms

Share to Nivolumab

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 39269823
DOI: 10.3233/CBM-230431
PMCID: PMC11491993

Genes

PIK3CA
BRCA1
CCND1
CTNNB1
KIT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab.PMID 39269823Read ↗

Circulating tumor DNA mutation analysis: advances in its application for early diagnosis of hepatocellular carcinoma and therapeutic efficacy monitoring.Semantic proximity Read ↗

Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib.Semantic proximity Read ↗

Molecular Profiling of Hepatocellular Carcinoma Using Circulating Cell-Free DNASemantic proximity Read ↗

Differential Mutation Detection Capability Through Capture-Based Targeted Sequencing in Plasma Samples in Hepatocellular CarcinomaSemantic proximity Read ↗

Plasma Circulating Tumor DNA Sequencing Reveals the Landscape of Acquired Mutations in Patients with Hepatocellular Carcinoma: a Potential Predictive Value in Liquid BiopsySemantic proximity Read ↗

Circulating tumor DNA as an emerging liquid biopsy biomarker for early diagnosis and therapeutic monitoring in hepatocellular carcinoma.Semantic proximity Read ↗

The potential clinical utility of cell-free DNA for gastric cancer patients treated with nivolumab monotherapySemantic proximity Read ↗

Genomic profiling in hepatocellular carcinoma: a real-world retrospective analysisSemantic proximity Read ↗

Real-Time Genomic Characterization Utilizing Circulating Cell-Free DNA in Patients with Anaplastic Thyroid Carcinoma.Semantic proximity Read ↗

Clinical significance of circulating biomarkers of immune checkpoint molecules with atezolizumab plus bevacizumab therapy in unresectable hepatocellular carcinomaSemantic proximity Read ↗

Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinomaSemantic proximity Read ↗

Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.