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Divergent effects of acute and chronic PPT1 inhibition in melanoma

12 Sept 2024

Abstract excerpt

Macroautophagy/autophagy-lysosome function promotes growth and survival of cancer cells, making them attractive targets for cancer therapy. One intriguing lysosomal target is PPT1 (palmitoyl-protein thioesterase 1). PPT1 inhibitors derived from chloroquine block autophagy, have significant antitumor activity in preclinical models and are being developed for clinical trials. However, the role of PPT1 in...

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PMID: 39265628
DOI: 10.1080/15548627.2024.2403152

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