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Article

ZCCHC8 p.P410A disrupts nucleocytoplasmic localization, promoting idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.

Molecular medicine (Cambridge, Mass.) - 10 Sept 2024

Wang Chen-Yu, Chang Si-Hua, Hu Cheng-Feng, Hu Yi-Qiao, Luo Hong, Liu Lv, Fan Liang-Liang

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a special kind of chronic interstitial lung disease with insidious onset. Previous studies have revealed that mutations in ZCCHC8 may lead to IPF. The aim of this study is to explore the ZCCHC8 mutations in Chinese IPF patients. METHODS: Here, we enrolled 124 patients with interstitial lung disease from 2017 to 2023 in our hospital. Whole exome sequencing and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39256642
DOI: 10.1186/s10020-024-00913-9
PMCID: PMC11389302

Genes

ZCCHC8
DKC1
RTEL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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