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Article

Identification of colorectal cancer molecular subtypes and prognostic features based on basement membrane-related genes.

Journal of applied genetics - 1 Sept 2026

Yang Leilei, Ji Zhiqing, Ren Yufeng, Fang Chengfeng, Han Jiaju, Luo Dinghai, Zhang Ruili, Zhou Shenkang

Abstract excerpt

Recent evidence suggests that the basement membrane (BM) plays an important role in the progression of colorectal cancer (CRC). Here, we investigate the prognostic value of CRC based on BM-associated genes. BM-related differentially expressed genes (DEGs) in CRC were obtained through analysis of The Cancer Genome Atlas public database and literature. The DEGs were used to cluster tumor samples and perform...

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
Prognosis
Basement Membrane
Gene Expression Regulation, Neoplastic
Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Profiling

Tumor Microenvironment

Nomograms

Survival Analysis

Mutation

Source

Identifiers

PMID: 40751879
DOI: 10.1007/s13353-025-00992-2

Genes

ADAMTS6
AGRN
MMP1
SPARCL1
TIMP1
UNC5A
UNC5C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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