Article
Unlocking the puzzle: non-defining mutations in SARS-CoV-2 proteome may affect vaccine effectiveness.
Frontiers in public health - 1 Jan 2024
Ulzurrun Eugenia, Grande-Pérez Ana, Del Hoyo Daniel, Guevara Cesar, Gil Carmen, Sorzano Carlos Oscar, Campillo Nuria E
Abstract excerpt
Introduction: SARS-CoV-2 variants are defined by specific genome-wide mutations compared to the Wuhan genome. However, non-clade-defining mutations may also impact protein structure and function, potentially leading to reduced vaccine effectiveness. Our objective is to identify mutations across the entire viral genome rather than focus on individual mutations that may be associated with vaccine failure and to...
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