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Article

Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype.

Frontiers in immunology - 1 Jan 2024

Ansari Abdul Wahid, Jayakumar Manju Nidagodu, Ahmad Fareed, Venkatachalam Thenmozhi, Salameh Laila, Unnikannan Hema, Raheed Thesni, Mohammed Abdul Khader, Mahboub Bassam, Al-Ramadi Basel K, Hamid Qutayba, Steinhoff Martin, Hamoudi Rifat

Abstract excerpt

Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism of action is not fully understood. Given the involvement of the CD27 pathway in the pathophysiology of various T-lymphocyte-mediated inflammatory, autoimmune, and lymphoproliferative diseases, we examined the impact of AZM on CD27 regulation and potential...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39211048
DOI: 10.3389/fimmu.2024.1447625
PMCID: PMC11357905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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