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The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives.

Journal of integrative neuroscience - 19 Aug 2024

Mohamed Wael, Eltantawi Mohamed Abdelhalim, Agarwal Vidhu, Bandres-Ciga Sara, Makarious Mary B, Mecheri Yasser, Zewde Yared Zenebe, Kamel Walaa A, Al-Mubarak Bashayer, Alzoubi Karem H, Kissani Najib, Alghamdi Badrah S, Sassi Samia Ben

Abstract excerpt

Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide...

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PMID: 39207075
DOI: 10.31083/j.jin2308152

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