Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.

doi:10.1038/s41598-024-70471-x

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Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.

Scientific reports - 23 Aug 2024

Wang Linfeng, Lim Dodge R, Phelan Jody E, Reyes Lorenzo T, Palparan Alma G, Sanchez Maria Guileane C, Asuncion Louella Abigail A, Tujan Ma Angelica A, Medado Inez Andrea P, Daga Chona Mae A, Llames Jo-Hannah S, Mitarai Satoshi, Murase Yoshiro, Morishige Yuta, Ang Concepcion F, Malabad John Carlo M, Montoya Jaime C, Hafalla Julius C, Campino Susana, Hibberd Martin L, Ama Cecilia G, Basilio Ramon P, La Paz Eva Maria Cutiongoco-De, Clark Taane G

Abstract excerpt

The Philippines is a high-incidence country for tuberculosis, with the increasing prevalence of multi- (MDR-TB) and extensively-drug (XDR-TB) resistant Mycobacterium tuberculosis strains posing difficulties to disease control. Understanding the genetic diversity of circulating strains can provide insights into underlying drug resistance mutations and transmission dynamics, thereby assisting the design of...

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Identifiers

PMID: 39179783
DOI: 10.1038/s41598-024-70471-x
PMCID: PMC11344074

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