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Article

Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development.

EBioMedicine - 1 Sept 2024

Russo Thomas A, Carlino-MacDonald Ulrike, Drayer Zachary J, Davies Connor J, Alvarado Cassandra L, Hutson Alan, Luo Ting L, Martin Melissa J, McGann Patrick T, Lebreton Francois

Abstract excerpt

BACKGROUND: Quantitating the contribution of phenotype-responsible elements in hypervirulent Klebsiella pneumoniae is needed. METHODS: Isogenic mutants of four hypervirulent clinical isolates that produced K1 (ST23), K2 (ST86), K20 (ST1544), or K54 (ST29) capsules (mean 2.2 log10 LD50 (range 1.5-2.9)) were created to measure the effects on LD50 in a murine model of the hypervirulence-associated plasmid (pVir),...

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Identifiers

PMID: 39178743
DOI: 10.1016/j.ebiom.2024.105302
PMCID: PMC11388194

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